Neuroblastoma Risk Develops With Age; Shows a New Study


Neuroblastoma Risk Develops With Age; Shows a New Study

According to a new analysis, it has been accounted that tumors have a characteristic mutation, ATRX. Following a genetic analysis of neuroblastoma samples from infants and young adults, it was concluded that tumor encountered in case of adults was due to a high frequency of specific mutation. However, the presence of this mutation was not being seen in infants or children.

The investigators of the study carried out an analysis on 40 patients with metastatic melanoma. The whole genome sequencing on DNA of tumor samples was carried out. This group was termed as ‘discovery cohort’. They also considered the tumor samples of 64 patients, whose tumors were examined in the last few years. They termed this group as validation cohort.

The findings from the discovery cohort showed that the infants younger than 18 months showed no signs of these mutations, children between the age 18 months and 12 years- 29 samples were analyzed, out of which, in only five cases these mutations were identified, and in case of 12 years and older, the mutations were observed in the total five of five samples.

The results that came into notice for the validation cohort were, out of the 27 samples from adolescents or young adults, nine were found carrying these mutations, out of the 25 samples from children between 18 months to 12 years, 4 cases were registered of this mutation and in case of infants, none of the samples was found carrying the mutation.

The mutations were expected to be related to the ATRX protein in nucleus and long telomeres. These are all a part of stages encountered during cell division.

Coinvestigator Alberto Pappo, MD, Director of the Solid Tumor Division at St. Jude's said, “The presence of ATRX appears to identify a subset of patients with neuroblastoma who are older than 5 years of age and lack MYCN amplification”.

They stated that the findings have helped them find better molecular markers and treatment.

Latest News

Morgan Stanley to Trim Jobs in its Debt and Currencies Divisions
New Rule Restricts Federal Reserve’s Bailout Powers during Crisis
China’s Weak Manufacturing PMI Puts the Government’s Growth Target at Risk
Clean Energy Research to get Historic Investment during the United Nations
Investors Keenly Wait for OPEC Meeting; Oil Prices Move Up a Little
Amazon Testing Drones in Multiple International Locations
NextEra Agrees to Sell Two Texas Power Plants to Luminant
China’s Yuan Could be Named a Reserve Currency by the IMF
Rupert Murdoch Tweets Tribune Probably Selling Los Angeles Times
Black Friday Shopping “Uninspiring” in Brick and Mortar Stores; Shopping Trends
U.S. Crude Drops Further Due to Surplus Supply
CVC and CPPIB Outbid Others for a Possible Deal to Buy Petco for $4.7 Billion