A new research has proposed that the heart of a person can well regulate energy balance throughout body. It has been discovered that this study is the first of its kind to come up with the results which prove heart to be a regulator of the body.
A team of researchers from UT Southwestern Medical Center, carried out an experimental analysis on a genetically altered mouse, during which, they fed the mouse with a diet rich in fats. It was explained that the heart is assisted with two molecules, which are responsible for regulation. A drug which was capable to influence the working of these two molecules was even used in the analysis.
It was discovered that gene MED13, played an important role in gene pathway in the heart, which is responsible for managing the metabolism of body. These genes are responsible for protein coding. Another gene miRNA-208a, a heart-specific microRNA, was acknowledged, which inhibited the action of MED13.
It was analyzed that in case of mice, whose levels of MED13 were genetically altered and hence, increased or due to the manipulation of the drug, increase, were able to show up with an increase in energy levels.
However, in case of mice, whose levels of MED13 were decreased, had higher chances of getting obese due to the diet, they were given. Moreover, it was administered that the blood-sugar levels even fluctuated. Nevertheless, it was administered that the group of mice showed similar conditions as the ones encountered in case of people suffering from metabolic syndrome, including coronary artery disease, stroke, and type 2 diabetes.
Dr. Eric Olson, Senior Author of the study, said, “Several years ago, we worked with a biotechnology company to develop a drug to inhibit miR-208a. While studying the effects of that drug, we observed that animals treated with the inhibitor seemed to be resistant to high-fat diets”. The study has been able to put forth the role of miR-208a in regulating metabolism.
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