In a landmark development for neurodevelopmental healthcare, the U.S. Food and Drug Administration (FDA) has approved leucovorin, a folate-based medication, for the treatment of autism spectrum disorder (ASD). The decision represents a significant step forward in addressing the complex medical needs of individuals with autism, a condition that affects millions worldwide. Clinical trials demonstrated that leucovorin can improve communication, social interaction, and behavioral outcomes in certain subgroups of patients, particularly those with folate metabolism irregularities.